10,000 Norwegians have this dangerous disease without knowing about it.
Familial hypercholesterolaemia (FH)
– Familiar means that it is a property that goes with families
– Hypercholesterolemia means high blood cholesterol levels (the recommendation is 5 mmol / L; the fat in the blood is measured in unit millimol per liter (mmol / l).
– Norway’s most common hereditary disease with single or double gene defects that increase the risk of cardiovascular disease:
- Double gene defects cause high blood cholesterol in the 20-25 mmol / L blood and can treat untreated heart disease at childhood
- Simple gene failure gives cholesterol 7-15 mmol / L and can treat untreated heart disease in adulthood
- If one parent has FH, there is a 50% chance that the child will receive FH
Source: Oslo University Hospital
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Familial hypercholesterolemia (FH) is Norway’s most prevalent genetic disease that causes high blood cholesterol levels and increased risk of heart disease.
The disease is about as large in prevalence as the more known disease celiac disease. Nevertheless, it is assumed that 10. 000 Norwegians have this genetic hereditary disease without knowing about it.
– Many people go around with high cholesterol levels, and FH, without knowing it. You can not notice it on your body if you have high cholesterol levels, so it’s important to measure your cholesterol level, “says Professor at the University of Oslo and chief physician Kjetil Retterstøl.
At FH, more of the receptors are missing the “bad” cholesterol (LDL cholesterol) from the blood.
Thus, cholesterol levels are high, which can lead to adverse blood vessel delays and increased risk of cardiovascular disease.
Only 1 in 3 is detected
In excess of 6000 Norwegians, the diagnosis of FH is certainly determined by the gentest. About 10. 000 more have the disease, which gives hereditary high cholesterol levels, without knowing about it yet.
Treatment of FH is done with dietary remedies and cholesterol-mediated drugs.
– One does not feel sick of FH, but it is still a disease, says a senior doctor and professor at the University of Oslo, Leiv Ose, who started LipidHonest Homeen, affiliated with Oslo University Hospital, 30 years ago.
Lipid clinics specialize in the treatment of people with hereditary high cholesterol levels.
Recently, the Lipid Clinic has gained status as a national competence service, providing information about cholesterol, a heartbeat diet and new knowledge about FH.
In addition to developing, researching and improving treatment for this group in Norway.
Will identify more patients
“The whole point of the competence service is to identify more people with FH,” says Ole Ose, who believes that the lack of knowledge, both among general practitioners and most people, is the main reason for as many as 10. 000 Norwegians are believed to have hereditary high cholesterol levels without knowing about it.
Retterstøl also believes that about 30 percent of all Norwegians have never measured their cholesterol levels earlier, according to a survey conducted by Synovate in 2007.
This check should take you from the age of 20
– Lover in Norway also forbids us to make direct contact with people we suspect to have FH, as relatives of famous FH patients. This makes it difficult to find more, Ose adds.
Ose therefore believes that this law should be repealed, as in other European countries. This will increase the possibilities of discovering more with FH considerably.
A study conducted in the 1990s showed that a majority of the Norwegian population had a desire to be contacted directly if there was suspicion of hereditary high cholesterol levels in the family.
Who should check for FH (hereditary high cholesterol level)?
The fat in the blood is measured in unit millimol per liter (mmol / l).
A cholesterol level in the blood (total cholesterol) of less than 5 mmol / L is optimal.
What happens in the body at FH?
The body lacks several receptors that remove bad LDL cholesterol. Cholesterol levels get high, which can lead to adverse blood vessel delays.
- The diagnosis is made by gentest, but blood tests and family history review are important before taking a gentle
- Treatment of FH is done with dietary remedies and cholesterol-lowering drugs
- In Norway it is assumed that 1 in 300 has one of three types of gene errors that give FH
Source: Oslo University Hospital
The lipid clinic recommends that you check for FH if you have an elevated blood cholesterol level and / or if you or your parents or siblings have had cardiovascular disease early, that is before 50-60 years of age.
– If you have a total cholesterol of 6-8 mmol / L, with high levels of “bad cholesterol”, you should test for FH, “says Ose..
Five-fold elevated level
Ingunn Narverud at the University of Oslo has taken a doctorate on hereditary high cholesterol and how this affects factors in the development of cardiovascular disease already at a young age.
She has found that people with FH have measured cholesterol levels that are five times as high as the recommendations.
– It’s easy to test for FH by taking a gentest, this can be done as early as at birth, Narverud says..
Ose emphasizes that it’s vital to know if you have FH as early as possible.
If you do not discover FH, or choose to do nothing about it, you have a significantly increased risk of heart disease before the age of 50-60 years.
Some may have heart disease as early as 20-30 years of age.
– Fortunately, it’s the few that do like strutsen and stuck their heads in the sand when they get to know they have FH. Most people take the disease seriously and do something about it, says Ose.
Check if you have abnormal heartbeat
Good news on the food front
A cost reduction can lower your cholesterol.
– For people with hereditary high cholesterol levels, it is recommended to replace the unhealthy (saturated) fat found in foods such as butter, fat dairy products, greasy and processed meat products and pre-cooked biscuits and cakes, with healthy (unsaturated) fat from including fat fish, oil, nuts, avocado and lean meat products, says Narverud.
Fat with fat
The Norwegian dietary guidelines show convincing likelihood that replacing saturated fatty acids with unsaturated fatty acids reduces the risk of future cardiovascular disease.
– My slogan is “using fat with vits,” says Ose, referring to the recommendations as well as the website www. healthy fats. no, where you can get concrete tips and advice on how to use “fat with vett”.
If you have high cholesterol levels or are sensitive to cholesterol, Lipid cleansers also recommend that you consume eggs to 2-3 eggs per week because of the high cholesterol content of the egg yolk. Eggs and pork livery are the foods with the highest cholesterol content.
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“Good” and “bad” cholesterol
Cholesterol is included in various particles (eg LDL and HDL), including fats and proteins for transport in blood. LDL cholesterol is called “bad” cholesterol because the particle transports cholesterol to, among other things, the artery wall where cholesterol can be derived. These deposits are disadvantageous because it makes the blood vessels narrower and prevents maximum blood flow. Additionally, in the worst case cases, plaques can creep around the blood and cause blood clots or heart or heart infarction.
Conversely, HDL cholesterol is often called “good” cholesterol because it removes excess cholesterol from the artery wall, takes it into the cell where it is utilized or transported to the liver where it is excreted.
Source: Leiv Oses publication “Familiar Hypercholesterolemia”
Five tips for a more heart-healthy diet
1. Eat less fat, particularly saturated fat (animal fat). Saturated fat, there is a lot of fat fat and fat meat. Stick to the lean products and clean meat and chicken without skin.
2. Replace any saturated fat with unsaturated fat. Unsaturated grease is fat from the plant and fisheries label. Oils, soft plant margarines, nuts and oily fish are good sources.
3. Eat more fruits and vegetables, a total of 5 servings a day. Varies with different types of fruits and vegetables. Feel free to finish the meal with fruit and always have plenty of vegetables for dinner
4. Eat less cholesterol-rich foods. Stick to approx. 2 eggs per week and eat liver and feed max 1 time per month.
5. Use the least amount of sugar and alcohol at high triglycerides and overweight. Overweight with fat placed around the stomach is the main reason for excessive triglycerides. A lower energy intake and more exercise are therefore the main recommendations.
Source: Ellen Charlotte Stream, Lipid Clinic
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